If you’ve modified your fret board to be ‘hard wired’ (e.g. bypassing the body-to-neck connector), then you really don’t want the neck to be removed and risk pulling/damaging the wiring.
This simple solution replaces the stock unlock lever with a lever that fills the entire crescent-shaped slot. Simple, “easy” to install (once you’ve removed the 47 screws that hold the guitar body together).
Unscrew the stock lever and screw in the new Neck Lock lever. You can see the install process here.

Like everything else Guitar Hero, There are several different sizes/dimensions, so check carefully!  Check the Store Page for the guitars supported.